Bassiatin, a new platelet aggregation inhibitor produced by Beauveria bassiana K-717.
نویسندگان
چکیده
A new platelet aggregation inhibitor, bassiatin, was isolated from the cultured broth of Beauveria bassiana which had been isolated from a soil sample collected in Yunnan province, China. The structure of bassiatin was determined to be (3S, 6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1, 4-perhydrooxazine-2,5-dione by NMR analysis, X-ray crystallographic analysis and chemical synthesis. Bassiatin inhibited ADP-induced aggregation of rabbit platelets with the IC50 being 1.9 x 10(-4) M.
منابع مشابه
Purification and Properties of an Extracellular Protease Produced by the Entomopathogenic Fungus Beauveria bassiana.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 48 12 شماره
صفحات -
تاریخ انتشار 1995